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KMID : 0376219820190030343
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Chonnam Medical Journal
1982 Volume.19 No. 3 p.343 ~ p.348
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Changes in the Protein Profile of Erythrocyte Membrane by Membrane Peroxidation
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Abstract
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Ascorbic acid and dihydroxyfumaric acid, in the presence of ferrous sulfate, caused a lipid peroxidation in human erythrocyte membrane in vitro. Associated with the membrane lipid peroxidation, the spectrin component in the membrane polypeptides was selectively broken down and a new polypeptide fraction, which is- larger than the spectrin in molecular weight, emerged.
These results suggest that the cytoskeleton of erythrocytes is a primary site of damage caused by membrane lipid peroxidation.
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